Properties and Application of Ac-225
Properties and Application of 225 Ac Application : Targeted alpha therapy (TAT) nuclear medicine for the treatment of cancers (Prostate, Brain and Neuroendocrine). Injected as : 225 Ac -HEHA, 225 Ac -BF-HEHA complex, 225 Ac -DOTA complex HEHA: 1,4,7,10,13,16-hexaazacyclohexadecane-N,N′,N″,N‴,N′‴,N″‴-hexaacetic acid BF-HEHA: bifunctional HEHA DOTA: 1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acid. Major decay mode : Alpha particle Decay energy : 5.8 MeV (18.9%) α particle + 3 more = 28 MeV alpha Half-life ( t 1/2 ): 10 d Mode of Production Radioactive decay: 233 U (1.6x 10 5 a)(α) 229 Th (7932a)(α) 225 Ra (14.82d) (β-) 225 Ac Cyclotron/ Accelerator: 226 Ra(p,2n) 225 Ac 232 Th(p, x) 225 Ac (Spallation reaction) 226 Ra(γ,n) 225 Ra(β-) 225 Ac (Photonuclear reactions) Reactor: 226 Ra(n, 2n) 225 Ra Chemistry Separation in radionuclidic generator 229 Th/ 225 Ac : Selective adsorption of 22...